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B.S. Yale University; Ph.D. Massachusetts Institute of Technology
Areas of Expertise
Statistical thermodynamics of amphiphilic aggregates in solution; fluid phases of lipid monolayers and bilayers; lipid interactions with intrinsic membrane proteins; molecular mechanism of anesthesia.
Selected Works
Milutinovic, P S, L Yang, R S Cantor, E I Eger II, and J M Sonner, "Anesthetic-like Modulation of Gamma-aminobutyric Acid Type A, Strychnine-sensitive Glycine, and N-methyl-d-aspartate Receptors by Coreleased Neurotransmitters," Anesthesia & Analgesia, 105 (2007) 386-392.
Mohr, J T, G W Gribble, S S Lin, R G Eckenhoff, and R S Cantor, "Anesthetic Potency of Two Novel Synthetic Polyhydric Alkanols Longer than the n-Alkanol Cutoff: Evidence for a Bilayer-mediated Mechanism of Anesthesia?" Journal of Medicinal Chemistry, 48 (2005) 4172-4176.
"Receptor Desensitization by Neurotransmitters in Membranes: Are Neurotransmitters the Endogenous Anesthetics?" Biochemistry, 42 (2003) 11891-11897.
"Size Distribution of Barrel-stave Aggregates of Membrane Peptides: Influence of the Bilayer Lateral Pressure Profile," Biophysical Journal, 82 (2002) 2520-2525.
"Breaking the Meyer-Overton Rule: Predicted Effects of Varying Stiffness and Interfacial Activity on the Intrinsic Potency of Anesthetics," Biophysical Journal, 80 (2001) 2284-2297.
Current Projects
"Interactions of Fast Neurotransmitters and Volatile Anesthetics with Lipid Bilayers and Monolayers: Molecular Dynamics Simulations and Experimental Studies;" "Kinetic Modeling of Postsynaptic Ion Currents"
